It was Franklin's third victory in the season's first Grand Prix meet, having won the 200 freestyle with a national age-group record time Friday. In the 50 free, she touched in 22.15 seconds. Erin Caflisch was second at 22.75.
Franklin returned to the University of Minnesota pool to win her signature event, the 100 back in 50.97, nearly 3 seconds ahead of second-place finisher Mickayla Hinkle, who was timed in 53.55.
Lochte took the 100 back in 46.21, ahead of national team member David Plummer, who was second at 47.24. Lochte won the 200 free and 100 fly.
In the men's 50 free, Olympian Jimmy Feigen won in 19.73. Garrett Weber-Gale, a 2008 Olympian, was second at 20.11. Lochte also swam in the final, choosing to swim butterfly and finished last in 21.48.